21.enl0Barradas-Guevara, E.Félix-Beltrán, O.Gonzalez-Canales, F.Hernández, E. González-Rodríguez-Jáuregui, E.Zeleny-Mora, M.Analysis of the Lepton Mixing Matrix in the Two Higgs Doublet Model203-21912hdm-iiineutrinospmns matrixseesaw201610.15415/jnp.2016.41021internal-pdf://41021_JNP_OLGA.pdfhttp://arxiv.org/abs/1606.05388%0Ahttp://dx.doi.org/10.15415/jnp.2016.41021In the theoretical framework of Two Higgs Doublet Model (2HDM) plus three right-handed neutrinos we consider a universal treatment for the mass matrices, aside from that the active neutrinos acquire their small mass through the type-I seesaw mechanism. Then, as long as a matrix with four-zero texture is used to represent the right-handed neutrinos and Yukawa matrices, we obtain a unified treatment where all fermion mass matrices have four-zero texture. We obtain analytical and explicit expressions for the lepton flavour mixing matrix PMNS in terms of fermion masses and parameters associated with the 2HDM-III. Further, we compare these expressions of the PMNS matrix with the most up to date values of masses and mixing in the lepton sector, via a likelihood test $\chi^{2}$. We find that the analytical expressions that we derived reproduce remarkably well the most recent experimental data of neutrino oscillations.