GEANT4 Study of Proton–Body Interactions
Proton therapy uses a beam of protons to destroy cancer cells. A problem of the method is the determination of what part of the body the protons are hitting during the irradiation. In a previous study we determine that by capturing the gamma rays produced during the irradiation one can determine the location of the proton-body interaction, in this work we investigate if by examining the gamma rays produced it is possible to determine the body part that produced the gamma rays by the proton collision. This study uses GEANT4 computer simulations of interactions of proton-tissue, protonbrain, proton-bone, etc., which produce gamma rays, to determine the characteristics of the gamma rays produced. We then analyze the characteristics of the gamma rays to find signatures that could be used to determine the source of the rays. In particular, we study the distribution of gamma ray energies, their full-width half-maximum, energy resolution, maximum height, and total number of counts. This study concludes that it is possible to use the gamma ray spectra to determine what body part produced it.
K.A. Camphausen and R.C. Lawrence, Cancer Management: A Multidisciplinary Approach. In: Principles of Radiation Therapy, edited by R. Pazdur, L.D. Wagman, K.A. Camphausen and W.J. Hoskins, 11th ed., Cmp. United Business Media, 2009.
W.P. Levin, H. Kooy, J.S. Loeffler and T.F. DeLaney, British Journal of Cancer 93, 849 (2005). https://doi.org/10.1038/sj.bjc.6602754
W.D. Newhauser and R. Zhang, Phys. Med. Biol. 60, R155 (2015). https://doi.org/10.1088/0031-9155/60/8/R155
J. Metz, Differences between protons and X-rays. Abramson Cancer Center of the University of Pennsylvania, 2006. Retrieved on February 04, 2018 from http://www.oncolink.org/treatment/article.cfm?c=9&s=70&id=210.
J.A. López, S.S. Romero González, O. Hernández Rodríguez, J. Holmes and R. Alarcón, Journal of Nuclear Physics Material Sciences Radiation and Applications 7, 217 (2020). https://doi.org/10.15415/jnp.2020.72028
S.S. Romero Gonzalez, M.S. Thesis, University of Texas at El Paso, 2018. Retrieved on September 14, 2020 from https://scholarworks.utep.edu/dissertations/AAI10822888/.
R. Alarcon, D. Blyth, E. Galyaev, J. Holmes, L. Ice, G. Randall, M. Bues and M. Fatyga, Int. J. Modern Physics: Conference Series 44, 1660217 (2016). https://doi.org/10.1142/S2010194516602179.
Basics physics of nuclear medicine/interaction of radiation with matter. Retrieved on September 14, 2020 from https://en.wikibooks.org/wiki/Basic_Physics_of_Nuclear_Medicine/Interaction_of_Radiation_with_Matter.
Geant4 Collaboration. Introduction to Geant4. Retrieved on September 13, 2020 from http://geant4-userdoc.web.cern.ch/geant4-userdoc/UsersGuides/IntroductionToGeant4/html/index.html
http://www.sixiangguo.net/code/geant4/AppDevelop/apas06.html. Accessed 13 September, 2020.
O. Hernández Rodríguez, M.S. Thesis, University of Texas at El Paso, 2018. Retrieved on September 14, 2020 from https://scholarworks.utep.edu/dissertations/AAI10823026/.
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